Enhanced infection efficiency and cytotoxicity mediated by vpx-containing lentivirus in chimeric antigen receptor macrophage (CAR-M)
Genetically modified macrophage infusion has been proven to be a novel treatment for cancer.One of the most important processes in macrophage-based therapy is the efficient transfer of genes.HIV-1-derived lentiviruses were widely used as delivery vectors in chimeric antigen receptor T and NK cell construction.While macrophages are relatively refrac